You can do that with Norton and McAfee, and CLAM is still a bit iffy.
If your still looking Hamed, plump for the Norton/Symantec one.
Never had a problem on many corp networks with either, but Norton Enterprise (the server and workstation version) did sort of pip it by pushing updates immediately to the management console on server without waiting for scheduled updates when there was a high risk.
Neither McAfee or Norton have had an spread infection on any networks I've worked on, so they do hit any as soon as with constant monitoring.
If it's for one server only pick the cheapest of those 2 for a standard workstation version, it'll do the job just as well and set updating to every hour, sorted.